An exposome atlas of serum reveals the risk of chronic diseases in the Chinese population

Lei You, Jing Kou, Mengdie Wang, Guoqin Ji, Xiang Li, Chang Su, Fujian Zheng, Mingye Zhang, Yuting Wang, Tiantian Chen, Ting Li, Lina Zhou, Xianzhe Shi, Chunxia Zhao, Xinyu Liu (), Surong Mei () and Guowang Xu ()
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Lei You: Chinese Academy of Sciences
Jing Kou: Huazhong University of Science and Technology
Mengdie Wang: Chinese Academy of Sciences
Guoqin Ji: Chinese Academy of Sciences
Xiang Li: Huazhong University of Science and Technology
Chang Su: Chinese Center for Disease Control and Prevention
Fujian Zheng: Chinese Academy of Sciences
Mingye Zhang: Huazhong University of Science and Technology
Yuting Wang: Chinese Academy of Sciences
Tiantian Chen: Chinese Academy of Sciences
Ting Li: Chinese Academy of Sciences
Lina Zhou: Chinese Academy of Sciences
Xianzhe Shi: Chinese Academy of Sciences
Chunxia Zhao: Chinese Academy of Sciences
Xinyu Liu: Chinese Academy of Sciences
Surong Mei: Huazhong University of Science and Technology
Guowang Xu: Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Although adverse environmental exposures are considered a major cause of chronic diseases, current studies provide limited information on real-world chemical exposures and related risks. For this study, we collected serum samples from 5696 healthy people and patients, including those with 12 chronic diseases, in China and completed serum biomonitoring including 267 chemicals via gas and liquid chromatography-tandem mass spectrometry. Seventy-four highly frequently detected exposures were used for exposure characterization and risk analysis. The results show that region is the most critical factor influencing human exposure levels, followed by age. Organochlorine pesticides and perfluoroalkyl substances are associated with multiple chronic diseases, and some of them exceed safe ranges. Multi-exposure models reveal significant risk effects of exposure on hyperlipidemia, metabolic syndrome and hyperuricemia. Overall, this study provides a comprehensive human serum exposome atlas and disease risk information, which can guide subsequent in-depth cause-and-effect studies between environmental exposures and human health.

Date: 2024
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DOI: 10.1038/s41467-024-46595-z

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