Elevated blood remnant cholesterol and triglycerides are causally related to the risks of cardiometabolic multimorbidity

Yimin Zhao, Zhenhuang Zhuang, Yueying Li, Wendi Xiao, Zimin Song, Ninghao Huang, Wenxiu Wang, Xue Dong, Jinzhu Jia, Robert Clarke and Tao Huang ()
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Yimin Zhao: Peking University Third Hospital, Peking University
Zhenhuang Zhuang: Peking University
Yueying Li: Peking University
Wendi Xiao: Peking University
Zimin Song: Peking University
Ninghao Huang: Peking University
Wenxiu Wang: Peking University
Xue Dong: Peking University
Jinzhu Jia: Peking University
Robert Clarke: University of Oxford
Tao Huang: Peking University

Nature Communications, 2024, vol. 15, issue 1, 1-9

Abstract: Abstract The connection between triglyceride-rich lipoproteins and cardiometabolic multimorbidity, characterized by the concurrence of at least two of type 2 diabetes, ischemic heart disease, and stroke, has not been definitively established. We aim to examine the prospective associations between serum remnant cholesterol, triglycerides, and the risks of progression from first cardiometabolic disease to multimorbidity via multistate modeling in the UK Biobank. We also evaluate the causality of these associations via Mendelian randomization using 13 biologically relevant SNPs as the genetic instruments. Here we show that elevated remnant cholesterol and triglycerides are significantly associated with gradually higher risks of cardiometabolic multimorbidity, particularly the progression of ischemic heart disease to the multimorbidity of ischemic heart disease and type 2 diabetes. These results advocate for effective management of remnant cholesterol and triglycerides as a potential strategy in mitigating the risks of cardiometabolic multimorbidity.

Date: 2024
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DOI: 10.1038/s41467-024-46686-x

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