Lanthanide luminescence nanothermometer with working wavelength beyond 1500 nm for cerebrovascular temperature imaging in vivo

Yukai Wu, Fang Li, Yanan Wu, Hao Wang, Liangtao Gu, Jieying Zhang, Yukun Qi, Lingkai Meng, Na Kong, Yingjie Chai, Qian Hu, Zhenyu Xing, Wuwei Ren (), Fuyou Li () and Xingjun Zhu ()
Additional contact information
Yukai Wu: ShanghaiTech University
Fang Li: ShanghaiTech University
Yanan Wu: ShanghaiTech University
Hao Wang: ShanghaiTech University
Liangtao Gu: ShanghaiTech University
Jieying Zhang: ShanghaiTech University
Yukun Qi: ShanghaiTech University
Lingkai Meng: ShanghaiTech University
Na Kong: ShanghaiTech University
Yingjie Chai: Fudan University
Qian Hu: ShanghaiTech University
Zhenyu Xing: ShanghaiTech University
Wuwei Ren: ShanghaiTech University
Fuyou Li: Fudan University
Xingjun Zhu: ShanghaiTech University

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Nanothermometers enable the detection of temperature changes at the microscopic scale, which is crucial for elucidating biological mechanisms and guiding treatment strategies. However, temperature monitoring of micron-scale structures in vivo using luminescent nanothermometers remains challenging, primarily due to the severe scattering effect of biological tissue that compromises the imaging resolution. Herein, a lanthanide luminescence nanothermometer with a working wavelength beyond 1500 nm is developed to achieve high-resolution temperature imaging in vivo. The energy transfer between lanthanide ions (Er3+ and Yb3+) and H2O molecules, called the environment quenching assisted downshifting process, is utilized to establish temperature-sensitive emissions at 1550 and 980 nm. Using an optimized thin active shell doped with Yb3+ ions, the nanothermometer’s thermal sensitivity and the 1550 nm emission intensity are enhanced by modulating the environment quenching assisted downshifting process. Consequently, minimally invasive temperature imaging of the cerebrovascular system in mice with an imaging resolution of nearly 200 μm is achieved using the nanothermometer. This work points to a method for high-resolution temperature imaging of micron-level structures in vivo, potentially giving insights into research in temperature sensing, disease diagnosis, and treatment development.

Date: 2024
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DOI: 10.1038/s41467-024-46727-5

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