RETRACTED ARTICLE: Metal free cross-dehydrogenative N-N coupling of primary amides with Lewis basic amines

Subban Kathiravan (), Prakriti Dhillon, Tianshu Zhang and Ian A. Nicholls ()
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Subban Kathiravan: Linnaeus University
Prakriti Dhillon: Linnaeus University
Tianshu Zhang: Linnaeus University
Ian A. Nicholls: Linnaeus University

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Hydrazides, N-N containing structural motifs, are important due to their presence in a wide variety of biologically significant compounds. While the homo N-N coupling of two NH moieties to form the hydrazide N-N bond is well developed, the cross-dehydrogenative hetero N-N coupling remains very unevolved. Here we present an efficient intermolecular N-N cross-coupling of a series of primary benzamides with broad range of Lewis basic primary and secondary amines using PhI(OAc)2 as both a terminal oxidant and a cross-coupling mediator, without the need for metal catalysts, high temperatures, and inert atmospheres, and with substantial potential for use in the late-stage functionalization of drugs.

Date: 2024
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DOI: 10.1038/s41467-024-46890-9

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