A fungal core effector exploits the OsPUX8B.2–OsCDC48-6 module to suppress plant immunity

Xuetao Shi, Xin Xie, Yuanwen Guo, Junqi Zhang, Ziwen Gong, Kai Zhang, Jie Mei, Xinyao Xia, Haoxue Xia, Na Ning, Yutao Xiao, Qing Yang, Guo-Liang Wang and Wende Liu ()
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Xuetao Shi: Chinese Academy of Agricultural Sciences
Xin Xie: Chinese Academy of Agricultural Sciences
Yuanwen Guo: Chinese Academy of Agricultural Sciences
Junqi Zhang: Chinese Academy of Agricultural Sciences
Ziwen Gong: Chinese Academy of Agricultural Sciences
Kai Zhang: Chinese Academy of Agricultural Sciences
Jie Mei: Chinese Academy of Agricultural Sciences
Xinyao Xia: Chinese Academy of Agricultural Sciences
Haoxue Xia: Chinese Academy of Agricultural Sciences
Na Ning: Chinese Academy of Agricultural Sciences
Yutao Xiao: Chinese Academy of Agricultural Sciences
Qing Yang: Chinese Academy of Agricultural Sciences
Guo-Liang Wang: The Ohio State University
Wende Liu: Chinese Academy of Agricultural Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract Proteins containing a ubiquitin regulatory X (UBX) domain are cofactors of Cell Division Cycle 48 (CDC48) and function in protein quality control. However, whether and how UBX-containing proteins participate in host–microbe interactions remain unclear. Here we show that MoNLE1, an effector from the fungal pathogen Magnaporthe oryzae, is a core virulence factor that suppresses rice immunity by specifically interfering with OsPUX8B.2. The UBX domain of OsPUX8B.2 is required for its binding to OsATG8 and OsCDC48-6 and controls its 26 S proteasome–dependent stability. OsPUX8B.2 and OsCDC48-6 positively regulate plant immunity against blast fungus, while the high-temperature tolerance heat-shock protein OsBHT, a putative cytoplasmic substrate of OsPUX8B.2–OsCDC48-6, negatively regulates defense against blast infection. MoNLE1 promotes the nuclear migration and degradation of OsPUX8B.2 and disturbs its association with OsBHT. Given the high conservation of MoNLE1 among fungal isolates, plants with broad and durable blast resistance might be generated by engineering intracellular proteins resistant to MoNLE1.

Date: 2024
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DOI: 10.1038/s41467-024-46903-7

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