S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure

Jie Ma, Yang Li, Ping Li, Xinying Yang, Shuolin Zhu, Ke Ma, Fei Gao, Hai Gao, Hui Zhang, Xin-liang Ma, Jie Du and Yulin Li ()
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Jie Ma: Beijing Anzhen Hospital of Capital Medical University
Yang Li: Beijing Anzhen Hospital of Capital Medical University
Ping Li: Beijing Anzhen Hospital of Capital Medical University
Xinying Yang: Beijing Anzhen Hospital of Capital Medical University
Shuolin Zhu: Beijing Anzhen Hospital of Capital Medical University
Ke Ma: Beijing Anzhen Hospital of Capital Medical University
Fei Gao: Beijing Anzhen Hospital of Capital Medical University
Hai Gao: Beijing Anzhen Hospital of Capital Medical University
Hui Zhang: Northwestern University
Xin-liang Ma: Thomas Jefferson University
Jie Du: Beijing Anzhen Hospital of Capital Medical University
Yulin Li: Beijing Anzhen Hospital of Capital Medical University

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Heart failure is the prevalent complication of acute myocardial infarction. We aim to identify a biomarker for heart failure post-acute myocardial infarction. This observational study includes 1062 and 1043 patients with acute myocardial infarction in the discovery and validation cohorts, respectively. The outcomes are in-hospital and long-term heart failure events. S100A8/A9 is screened out through proteomic analysis, and elevated circulating S100A8/A9 is independently associated with heart failure in discovery and validation cohorts. Furthermore, the predictive value of S100A8/A9 is superior to the traditional biomarkers, and the addition of S100A8/A9 improves the risk estimation using traditional risk factors. We finally report causal effect of S100A8/A9 on heart failure in three independent cohorts using Mendelian randomization approach. Here, we show that S100A8/A9 is a predictor and potentially causal medicator for heart failure post-acute myocardial infarction.

Date: 2024
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DOI: 10.1038/s41467-024-46973-7

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