Pheromone-based communication influences the production of somatic extracellular vesicles in C. elegans

Agata Szczepańska, Katarzyna Olek, Klaudia Kołodziejska, Jingfang Yu, Abdulrahman Tudu Ibrahim, Laura Adamkiewicz, Frank C. Schroeder, Wojciech Pokrzywa () and Michał Turek ()
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Agata Szczepańska: Polish Academy of Sciences
Katarzyna Olek: International Institute of Molecular and Cell Biology in Warsaw
Klaudia Kołodziejska: Polish Academy of Sciences
Jingfang Yu: Cornell University
Abdulrahman Tudu Ibrahim: Polish Academy of Sciences
Laura Adamkiewicz: Polish Academy of Sciences
Frank C. Schroeder: Cornell University
Wojciech Pokrzywa: International Institute of Molecular and Cell Biology in Warsaw
Michał Turek: Polish Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-19

Abstract: Abstract Extracellular vesicles (EVs) are integral to numerous biological processes, yet it is unclear how environmental factors or interactions among individuals within a population affect EV-regulated systems. In Caenorhabditis elegans, the evolutionarily conserved large EVs, known as exophers, are part of a maternal somatic tissue resource management system. Consequently, the offspring of individuals exhibiting active exopher biogenesis (exophergenesis) develop faster. Our research focuses on unraveling the complex inter-tissue and social dynamics that govern exophergenesis. We found that ascr#10, the primary male pheromone, enhances exopher production in hermaphrodites, mediated by the G-protein-coupled receptor STR-173 in ASK sensory neurons. In contrast, pheromone produced by other hermaphrodites, ascr#3, diminishes exophergenesis within the population. This process is regulated via the neuropeptides FLP-8 and FLP-21, which originate from the URX and AQR/PQR/URX neurons, respectively. Our results reveal a regulatory network that controls the production of somatic EV by the nervous system in response to social signals.

Date: 2024
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DOI: 10.1038/s41467-024-47016-x

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