Optics miniaturization strategy for demanding Raman spectroscopy applications

Oleksii Ilchenko (), Yurii Pilhun, Andrii Kutsyk, Denys Slobodianiuk, Yaman Goksel, Elodie Dumont, Lukas Vaut, Chiara Mazzoni, Lidia Morelli, Sofus Boisen, Konstantinos Stergiou, Yaroslav Aulin, Tomas Rindzevicius, Thomas Emil Andersen, Mikael Lassen, Hemanshu Mundhada, Christian Bille Jendresen, Peter Alshede Philipsen, Merete Hædersdal and Anja Boisen
Additional contact information
Oleksii Ilchenko: Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics
Yurii Pilhun: Lightnovo ApS
Andrii Kutsyk: Lightnovo ApS
Denys Slobodianiuk: Taras Shevchenko National University of Kyiv
Yaman Goksel: Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics
Elodie Dumont: Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics
Lukas Vaut: Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics
Chiara Mazzoni: Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics
Lidia Morelli: Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics
Sofus Boisen: Lightnovo ApS
Konstantinos Stergiou: Lightnovo ApS
Yaroslav Aulin: Lightnovo ApS
Tomas Rindzevicius: Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics
Thomas Emil Andersen: Odense University Hospital and Research Unit of Clinical Microbiology, University of Southern Denmark
Mikael Lassen: Danish Fundamental Metrology
Hemanshu Mundhada: Cysbio ApS
Christian Bille Jendresen: Cysbio ApS
Peter Alshede Philipsen: Copenhagen University Hospital
Merete Hædersdal: Copenhagen University Hospital
Anja Boisen: Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Raman spectroscopy provides non-destructive, label-free quantitative studies of chemical compositions at the microscale as used on NASA’s Perseverance rover on Mars. Such capabilities come at the cost of high requirements for instrumentation. Here we present a centimeter-scale miniaturization of a Raman spectrometer using cheap non-stabilized laser diodes, densely packed optics, and non-cooled small sensors. The performance is comparable with expensive bulky research-grade Raman systems. It has excellent sensitivity, low power consumption, perfect wavenumber, intensity calibration, and 7 cm−1 resolution within the 400–4000 cm−1 range using a built-in reference. High performance and versatility are demonstrated in use cases including quantification of methanol in beverages, in-vivo Raman measurements of human skin, fermentation monitoring, chemical Raman mapping at sub-micrometer resolution, quantitative SERS mapping of the anti-cancer drug methotrexate and in-vitro bacteria identification. We foresee that the miniaturization will allow realization of super-compact Raman spectrometers for integration in smartphones and medical devices, democratizing Raman technology.

Date: 2024
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DOI: 10.1038/s41467-024-47044-7

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