Dermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice

Tatsuya Dokoshi, Yang Chen, Kellen J. Cavagnero, Gibraan Rahman, Daniel Hakim, Samantha Brinton, Hana Schwarz, Elizabeth A. Brown, Alan O’Neill, Yoshiyuki Nakamura, Fengwu Li, Nita H. Salzman, Rob Knight and Richard L. Gallo ()
Additional contact information
Tatsuya Dokoshi: San Diego
Yang Chen: San Diego
Kellen J. Cavagnero: San Diego
Gibraan Rahman: San Diego
Daniel Hakim: San Diego
Samantha Brinton: San Diego
Hana Schwarz: San Diego
Elizabeth A. Brown: San Diego
Alan O’Neill: San Diego
Yoshiyuki Nakamura: San Diego
Fengwu Li: San Diego
Nita H. Salzman: Medical College of Wisconsin
Rob Knight: San Diego
Richard L. Gallo: San Diego

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract The composition of the microbial community in the intestine may influence the functions of distant organs such as the brain, lung, and skin. These microbes can promote disease or have beneficial functions, leading to the hypothesis that microbes in the gut explain the co-occurrence of intestinal and skin diseases. Here, we show that the reverse can occur, and that skin directly alters the gut microbiome. Disruption of the dermis by skin wounding or the digestion of dermal hyaluronan results in increased expression in the colon of the host defense genes Reg3 and Muc2, and skin wounding changes the composition and behavior of intestinal bacteria. Enhanced expression Reg3 and Muc2 is induced in vitro by exposure to hyaluronan released by these skin interventions. The change in the colon microbiome after skin wounding is functionally important as these bacteria penetrate the intestinal epithelium and enhance colitis from dextran sodium sulfate (DSS) as seen by the ability to rescue skin associated DSS colitis with oral antibiotics, in germ-free mice, and fecal microbiome transplantation to unwounded mice from mice with skin wounds. These observations provide direct evidence of a skin-gut axis by demonstrating that damage to the skin disrupts homeostasis in intestinal host defense and alters the gut microbiome.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-47072-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47072-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-47072-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().