Estimating the effects of temperature on transmission of the human malaria parasite, Plasmodium falciparum

Eunho Suh (), Isaac J. Stopard, Ben Lambert, Jessica L. Waite, Nina L. Dennington, Thomas S. Churcher and Matthew B. Thomas
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Eunho Suh: The Pennsylvania State University
Isaac J. Stopard: Imperial College London
Ben Lambert: University of Oxford
Jessica L. Waite: The Pennsylvania State University
Nina L. Dennington: The Pennsylvania State University
Thomas S. Churcher: Imperial College London
Matthew B. Thomas: The Pennsylvania State University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Despite concern that climate change could increase the human risk to malaria in certain areas, the temperature dependency of malaria transmission is poorly characterized. Here, we use a mechanistic model fitted to experimental data to describe how Plasmodium falciparum infection of the African malaria vector, Anopheles gambiae, is modulated by temperature, including its influences on parasite establishment, conversion efficiency through parasite developmental stages, parasite development rate, and overall vector competence. We use these data, together with estimates of the survival of infected blood-fed mosquitoes, to explore the theoretical influence of temperature on transmission in four locations in Kenya, considering recent conditions and future climate change. Results provide insights into factors limiting transmission in cooler environments and indicate that increases in malaria transmission due to climate warming in areas like the Kenyan Highlands, might be less than previously predicted.

Date: 2024
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DOI: 10.1038/s41467-024-47265-w

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