Stress increases hepatic release of lipocalin 2 which contributes to anxiety-like behavior in mice

Lan Yan, Fengzhen Yang, Yajie Wang, Lingling Shi, Mei Wang, Diran Yang, Wenjing Wang, Yanbin Jia, Kwok-Fai So and Li Zhang ()
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Lan Yan: Jinan University
Fengzhen Yang: Jinan University
Yajie Wang: Jinan University
Lingling Shi: Jinan University
Mei Wang: Jinan University
Diran Yang: Jinan University
Wenjing Wang: Jinan University
Yanbin Jia: Jinan University
Kwok-Fai So: Jinan University
Li Zhang: Jinan University

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Chronic stress induces anxiety disorders via both neural pathways and circulating factors. Although many studies have elucidated the neural circuits involved in stress-coping behaviors, the origin and regulatory mechanism of peripheral cytokines in behavioural regulation under stress conditions are not fully understood. Here, we identified a serum cytokine, lipocalin 2 (LCN2), that was upregulated in participants with anxiety disorders. Using a mouse model of chronic restraint stress (CRS), circulating LCN2 was found to be related to stress-induced anxiety-like behaviour via modulation of neural activity in the medial prefrontal cortex (mPFC). These results suggest that stress increases hepatic LCN2 via a neural pathway, leading to disrupted cortical functions and behaviour.

Date: 2024
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DOI: 10.1038/s41467-024-47266-9

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