A plant NLR receptor employs ABA central regulator PP2C-SnRK2 to activate antiviral immunity

Shen Huang, Chunli Wang, Zixuan Ding, Yaqian Zhao, Jing Dai, Jia Li, Haining Huang, Tongkai Wang, Min Zhu, Mingfeng Feng, Yinghua Ji, Zhongkai Zhang and Xiaorong Tao ()
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Shen Huang: Nanjing Agricultural University
Chunli Wang: Nanjing Agricultural University
Zixuan Ding: Nanjing Agricultural University
Yaqian Zhao: Nanjing Agricultural University
Jing Dai: Nanjing Agricultural University
Jia Li: Nanjing Agricultural University
Haining Huang: Nanjing Agricultural University
Tongkai Wang: Nanjing Agricultural University
Min Zhu: Nanjing Agricultural University
Mingfeng Feng: Nanjing Agricultural University
Yinghua Ji: Jiangsu Academy of Agricultural Sciences
Zhongkai Zhang: National Tobacco Genetic Engineering Research Center
Xiaorong Tao: Nanjing Agricultural University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Defence against pathogens relies on intracellular nucleotide-binding, leucine-rich repeat immune receptors (NLRs) in plants. Hormone signaling including abscisic acid (ABA) pathways are activated by NLRs and play pivotal roles in defence against different pathogens. However, little is known about how hormone signaling pathways are activated by plant immune receptors. Here, we report that a plant NLR Sw-5b mimics the behavior of the ABA receptor and directly employs the ABA central regulator PP2C-SnRK2 complex to activate an ABA-dependent defence against viral pathogens. PP2C4 interacts with and constitutively inhibits SnRK2.3/2.4. Behaving in a similar manner as the ABA receptor, pathogen effector ligand recognition triggers the conformational change of Sw-5b NLR that enables binding to PP2C4 via the NB domain. This receptor-PP2C4 binding interferes with the interaction between PP2C4 and SnRK2.3/2.4, thereby releasing SnRK2.3/2.4 from PP2C4 inhibition to activate an ABA-specific antiviral immunity. These findings provide important insights into the activation of hormone signaling pathways by plant immune receptors.

Date: 2024
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DOI: 10.1038/s41467-024-47364-8

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