Multiplexed representation of others in the hippocampal CA1 subfield of female mice

Xiang Zhang, Qichen Cao, Kai Gao, Cong Chen, Sihui Cheng, Ang Li, Yuqian Zhou, Ruojin Liu, Jun Hao, Emilio Kropff () and Chenglin Miao ()
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Xiang Zhang: Peking university
Qichen Cao: Peking university
Kai Gao: Peking university
Cong Chen: Peking university
Sihui Cheng: Peking university
Ang Li: Peking university
Yuqian Zhou: Peking university
Ruojin Liu: Peking university
Jun Hao: Peking university
Emilio Kropff: Leloir Institute/IIBBA-CONICET
Chenglin Miao: Peking university

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Hippocampal place cells represent the position of a rodent within an environment. In addition, recent experiments show that the CA1 subfield of a passive observer also represents the position of a conspecific performing a spatial task. However, whether this representation is allocentric, egocentric or mixed is less clear. In this study we investigated the representation of others during free behavior and in a task where female mice learned to follow a conspecific for a reward. We found that most cells represent the position of others relative to self-position (social-vector cells) rather than to the environment, with a prevalence of purely egocentric coding modulated by context and mouse identity. Learning of a pursuit task improved the tuning of social-vector cells, but their number remained invariant. Collectively, our results suggest that the hippocampus flexibly codes the position of others in multiple coordinate systems, albeit favoring the self as a reference point.

Date: 2024
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DOI: 10.1038/s41467-024-47453-8

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