Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses

David Morizet (), Isabelle Foucher, Alessandro Alunni and Laure Bally-Cuif ()
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David Morizet: Team supported by the Ligue Nationale Contre le Cancer
Isabelle Foucher: Team supported by the Ligue Nationale Contre le Cancer
Alessandro Alunni: Team supported by the Ligue Nationale Contre le Cancer
Laure Bally-Cuif: Team supported by the Ligue Nationale Contre le Cancer

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Macroglia fulfill essential functions in the adult vertebrate brain, producing and maintaining neurons and regulating neuronal communication. However, we still know little about their emergence and diversification. We used the zebrafish D. rerio as a distant vertebrate model with moderate glial diversity as anchor to reanalyze datasets covering over 600 million years of evolution. We identify core features of adult neurogenesis and innovations in the mammalian lineage with a potential link to the rarity of radial glia-like cells in adult humans. Our results also suggest that functions associated with astrocytes originated in a multifunctional cell type fulfilling both neural stem cell and astrocytic functions before these diverged. Finally, we identify conserved elements of macroglial cell identity and function and their time of emergence during evolution.

Date: 2024
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DOI: 10.1038/s41467-024-47484-1

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