CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits

Annemart Koornneef, Kanika Vanshylla, Gijs Hardenberg, Lucy Rutten, Nika M. Strokappe, Jeroen Tolboom, Jessica Vreugdenhil, Karin Feddes- de Boer, Aditya Perkasa, Sven Blokland, Judith A. Burger, Wei-Chiao Huang, Jonathan F. Lovell, Danielle Manen, Rogier W. Sanders, Roland C. Zahn, Hanneke Schuitemaker, Johannes P. M. Langedijk () and Frank Wegmann ()
Additional contact information
Annemart Koornneef: Janssen Vaccines & Prevention
Kanika Vanshylla: Janssen Vaccines & Prevention
Gijs Hardenberg: Janssen Vaccines & Prevention
Lucy Rutten: Janssen Vaccines & Prevention
Nika M. Strokappe: Janssen Vaccines & Prevention
Jeroen Tolboom: Janssen Vaccines & Prevention
Jessica Vreugdenhil: Janssen Vaccines & Prevention
Karin Feddes- de Boer: Janssen Vaccines & Prevention
Aditya Perkasa: Janssen Vaccines & Prevention
Sven Blokland: Janssen Vaccines & Prevention
Judith A. Burger: University of Amsterdam, Amsterdam Institute for Infection and Immunity
Wei-Chiao Huang: University at Buffalo
Jonathan F. Lovell: University at Buffalo
Danielle Manen: Janssen Vaccines & Prevention
Rogier W. Sanders: University of Amsterdam, Amsterdam Institute for Infection and Immunity
Roland C. Zahn: Janssen Vaccines & Prevention
Hanneke Schuitemaker: Janssen Vaccines & Prevention
Johannes P. M. Langedijk: Janssen Vaccines & Prevention
Frank Wegmann: Janssen Vaccines & Prevention

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract One of the strategies towards an effective HIV-1 vaccine is to elicit broadly neutralizing antibody responses that target the high HIV-1 Env diversity. Here, we present an HIV-1 vaccine candidate that consists of cobalt porphyrin-phospholipid (CoPoP) liposomes decorated with repaired and stabilized clade C HIV-1 Env trimers in a prefusion conformation. These particles exhibit high HIV-1 Env trimer decoration, serum stability and bind broadly neutralizing antibodies. Three sequential immunizations of female rabbits with CoPoP liposomes displaying a different clade C HIV-1 gp140 trimer at each dosing generate high HIV-1 Env-specific antibody responses. Additionally, serum neutralization is detectable against 18 of 20 multiclade tier 2 HIV-1 strains. Furthermore, the peak antibody titers induced by CoPoP liposomes can be recalled by subsequent heterologous immunization with Ad26-encoded membrane-bound stabilized Env antigens. Hence, a CoPoP liposome-based HIV-1 vaccine that can generate cross-clade neutralizing antibody immunity could potentially be a component of an efficacious HIV-1 vaccine.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-47492-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47492-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-47492-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().