Multiple processes of vocal sensory-motor interaction in primate auditory cortex

Joji Tsunada, Xiaoqin Wang and Steven J. Eliades ()
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Joji Tsunada: University of Pennsylvania Perelman School of Medicine
Xiaoqin Wang: Johns Hopkins University School of Medicine
Steven J. Eliades: University of Pennsylvania Perelman School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Sensory-motor interactions in the auditory system play an important role in vocal self-monitoring and control. These result from top-down corollary discharges, relaying predictions about vocal timing and acoustics. Recent evidence suggests such signals may be two distinct processes, one suppressing neural activity during vocalization and another enhancing sensitivity to sensory feedback, rather than a single mechanism. Single-neuron recordings have been unable to disambiguate due to overlap of motor signals with sensory inputs. Here, we sought to disentangle these processes in marmoset auditory cortex during production of multi-phrased ‘twitter’ vocalizations. Temporal responses revealed two timescales of vocal suppression: temporally-precise phasic suppression during phrases and sustained tonic suppression. Both components were present within individual neurons, however, phasic suppression presented broadly regardless of frequency tuning (gating), while tonic was selective for vocal frequencies and feedback (prediction). This suggests that auditory cortex is modulated by concurrent corollary discharges during vocalization, with different computational mechanisms.

Date: 2024
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DOI: 10.1038/s41467-024-47510-2

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