Capturing heterogeneity in PDX models: representation matters

Hari Shankar Sunil and Kathryn A. O’Donnell ()
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Hari Shankar Sunil: UT Southwestern Medical Center
Kathryn A. O’Donnell: UT Southwestern Medical Center

Nature Communications, 2024, vol. 15, issue 1, 1-3

Abstract: Patient derived tumor xenografts (PDXs) are important models for pre-clinical testing in cancer research and personalized medicine. PDXs often represent patient tumors with high similarity in terms of histology and driver mutations. However, certain limitations exist that warrant a detailed understanding of PDX heterogeneity and evolution. Hynds et al. demonstrate the relevance of primary tumor heterogeneity in PDX model establishment and explore multi-region sampling to determine the extent to which PDXs represent primary tumors.

Date: 2024
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DOI: 10.1038/s41467-024-47607-8

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