Genetic association of inflammatory marker GlycA with lung function and respiratory diseases

Yanjun Guo (), Quanhong Liu, Zhilin Zheng, Mengxia Qing, Tianci Yao, Bin Wang, Min Zhou, Dongming Wang, Qinmei Ke, Jixuan Ma, Zhilei Shan and Weihong Chen ()
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Yanjun Guo: Huazhong University of Science and Technology
Quanhong Liu: Huazhong University of Science and Technology
Zhilin Zheng: Huazhong University of Science and Technology
Mengxia Qing: Huazhong University of Science and Technology
Tianci Yao: Huazhong University of Science and Technology
Bin Wang: Huazhong University of Science and Technology
Min Zhou: Huazhong University of Science and Technology
Dongming Wang: Huazhong University of Science and Technology
Qinmei Ke: Huazhong University of Science and Technology
Jixuan Ma: Huazhong University of Science and Technology
Zhilei Shan: Huazhong University of Science and Technology
Weihong Chen: Huazhong University of Science and Technology

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Association of circulating glycoprotein acetyls (GlycA), a systemic inflammation biomarker, with lung function and respiratory diseases remain to be investigated. We examined the genetic correlation, shared genetics, and potential causality of GlycA (N = 115,078) with lung function and respiratory diseases (N = 497,000). GlycA showed significant genetic correlation with FEV1 (rg = −0.14), FVC (rg = −0.18), asthma (rg = 0.21) and COPD (rg = 0.31). We consistently identified ten shared loci (including chr3p21.31 and chr8p23.1) at both SNP and gene level revealing potential shared biological mechanisms involving ubiquitination, immune response, Wnt/β-catenin signaling, cell growth and differentiation in tissues or cells including blood, epithelium, fibroblast, fetal thymus, and fetal intestine. Genetically elevated GlycA was significantly correlated with lung function and asthma susceptibility (354.13 ml decrement of FEV1, 442.28 ml decrement of FVC, and 144% increased risk of asthma per SD increment of GlycA) from MR analyses. Our findings provide insights into biological mechanisms of GlycA in relating to lung function, asthma, and COPD.

Date: 2024
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DOI: 10.1038/s41467-024-47845-w

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