Population pharmacokinetic modelling of primaquine exposures in lactating women and breastfed infants

Thanaporn Wattanakul, Mary Ellen Gilder, Rose McGready, Warunee Hanpithakpong, Nicholas P. J. Day, Nicholas J. White, François Nosten, Joel Tarning and Richard M. Hoglund ()
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Thanaporn Wattanakul: Mahidol University
Mary Ellen Gilder: Mahidol University
Rose McGready: Mahidol University
Warunee Hanpithakpong: Mahidol University
Nicholas P. J. Day: Mahidol University
Nicholas J. White: Mahidol University
François Nosten: Mahidol University
Joel Tarning: Mahidol University
Richard M. Hoglund: Mahidol University

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Current guidelines advise against primaquine treatment for breastfeeding mothers to avoid the potential for haemolysis in infants with G6PD deficiency. To predict the haemolytic risk, the amount of drug received from the breast milk and the resulting infant drug exposure need to be characterised. Here, we develop a pharmacokinetic model to describe the drug concentrations in breastfeeding women using venous, capillary, and breast milk data. A mother-to-infant model is developed to mimic the infant feeding pattern and used to predict their drug exposures. Primaquine and carboxyprimaquine exposures in infants are

Date: 2024
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DOI: 10.1038/s41467-024-47908-y

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