Crown ether decorated silicon photonics for safeguarding against lead poisoning

Luigi Ranno, Yong Zen Tan, Chi Siang Ong, Xin Guo, Khong Nee Koo, Xiang Li, Wanjun Wang, Samuel Serna, Chongyang Liu, Rusli, Callum G. Littlejohns, Graham T. Reed, Juejun Hu, Hong Wang and Jia Xu Brian Sia ()
Additional contact information
Luigi Ranno: Massachusetts Institute of Technology
Yong Zen Tan: Fingate Technologies Pte Ltd
Chi Siang Ong: Fingate Technologies Pte Ltd
Xin Guo: Nanyang Technological University
Khong Nee Koo: Kampung Kerinchi
Xiang Li: Nanyang Technological University
Wanjun Wang: Nanyang Technological University
Samuel Serna: Massachusetts Institute of Technology
Chongyang Liu: Nanyang Technological University
Rusli: Nanyang Technological University
Callum G. Littlejohns: University of Southampton
Graham T. Reed: University of Southampton
Juejun Hu: Massachusetts Institute of Technology
Hong Wang: Nanyang Technological University
Jia Xu Brian Sia: Massachusetts Institute of Technology

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Lead (Pb2+) toxification is a concerning, unaddressed global public health crisis that leads to 1 million deaths annually. Yet, public policies to address this issue have fallen short. This work harnesses the unique abilities of crown ethers, which selectively bind to specific ions. This study demonstrates the synergistic integration of highly-scalable silicon photonics, with crown ether amine conjugation via Fischer esterification in an environmentally-friendly fashion. This realizes an integrated photonic platform that enables the in-operando, highly-selective and quantitative detection of various ions. The development dispels the existing notion that Fischer esterification is restricted to organic compounds, facilitating the subsequent amine conjugation for various crown ethers. The presented platform is specifically engineered for selective Pb2+ detection, demonstrating a large dynamic detection range, and applicability to field samples. The compatibility of this platform with cost-effective manufacturing indicates the potential for pervasive implementation of the integrated photonic sensor technology to safeguard against societal Pb2+ poisoning.

Date: 2024
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DOI: 10.1038/s41467-024-47938-6

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