Post-COVID conditions following COVID-19 vaccination: a retrospective matched cohort study of patients with SARS-CoV-2 infection

Debbie E. Malden (), In-Lu Amy Liu, Lei Qian, Lina S. Sy, Bruno J. Lewin, Dawn T. Asamura, Denison S. Ryan, Cassandra Bezi, Joshua T. B. Williams, Robyn Kaiser, Matthew F. Daley, Jennifer C. Nelson, David L. McClure, Ousseny Zerbo, Michelle L. Henninger, Candace C. Fuller, Eric S. Weintraub, Sharon Saydah and Sara Y. Tartof
Additional contact information
Debbie E. Malden: Department of Research & Evaluation
In-Lu Amy Liu: Department of Research & Evaluation
Lei Qian: Department of Research & Evaluation
Lina S. Sy: Department of Research & Evaluation
Bruno J. Lewin: Department of Research & Evaluation
Dawn T. Asamura: Department of Research & Evaluation
Denison S. Ryan: Department of Research & Evaluation
Cassandra Bezi: Department of Research & Evaluation
Joshua T. B. Williams: Ambulatory Care Services & Center for Health Systems Research
Robyn Kaiser: HealthPartners Institute
Matthew F. Daley: Institute for Health Research
Jennifer C. Nelson: Kaiser Permanente Washington Health Research Institute (KPWHRI)
David L. McClure: Marshfield Clinic Research Institute
Ousseny Zerbo: Vaccine Study Center
Michelle L. Henninger: Center for Health Research
Candace C. Fuller: Harvard Pilgrim Health Care Institute
Eric S. Weintraub: Immunization Safety Office
Sharon Saydah: Immunization Safety Office
Sara Y. Tartof: Department of Research & Evaluation

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract COVID-19 vaccinations protect against severe illness and death, but associations with post-COVID conditions (PCC) are less clear. We aimed to evaluate the association between prior COVID-19 vaccination and new-onset PCC among individuals with SARS-CoV-2 infection across eight large healthcare systems in the United States. This retrospective matched cohort study used electronic health records (EHR) from patients with SARS-CoV-2 positive tests during March 2021-February 2022. Vaccinated and unvaccinated COVID-19 cases were matched on location, test date, severity of acute infection, age, and sex. Vaccination status was ascertained using EHR and integrated data on externally administered vaccines. Adjusted relative risks (RRs) were obtained from Poisson regression. PCC was defined as a new diagnosis in one of 13 PCC categories 30 days to 6 months following a positive SARS-CoV-2 test. The study included 161,531 vaccinated COVID-19 cases and 161,531 matched unvaccinated cases. Compared to unvaccinated cases, vaccinated cases had a similar or lower risk of all PCC categories except mental health disorders (RR: 1.06, 95% CI: 1.02–1.10). Vaccination was associated with ≥10% lower risk of sensory (RR: 0.90, 0.86–0.95), circulatory (RR: 0.88, 0.83–0.94), blood and hematologic (RR: 0.79, 0.71–0.89), skin and subcutaneous (RR: 0.69, 0.66–0.72), and non-specific COVID-19 related disorders (RR: 0.53, 0.51–0.56). In general, associations were stronger at younger ages but mostly persisted regardless of SARS-CoV-2 variant period, receipt of ≥3 vs. 1–2 vaccine doses, or time since vaccination. Pre-infection vaccination was associated with reduced risk of several PCC outcomes and hence may decrease the long-term consequences of COVID-19.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-48022-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48022-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-48022-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().