Localized and global representation of prior value, sensory evidence, and choice in male mouse cerebral cortex

Kotaro Ishizu, Shosuke Nishimoto, Yutaro Ueoka and Akihiro Funamizu ()
Additional contact information
Kotaro Ishizu: University of Tokyo, Laboratory of Neural Computation, 1-1-1 Yayoi, Bunkyo-ku
Shosuke Nishimoto: University of Tokyo, Laboratory of Neural Computation, 1-1-1 Yayoi, Bunkyo-ku
Yutaro Ueoka: University of Tokyo, Laboratory of Neural Computation, 1-1-1 Yayoi, Bunkyo-ku
Akihiro Funamizu: University of Tokyo, Laboratory of Neural Computation, 1-1-1 Yayoi, Bunkyo-ku

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract Adaptive behavior requires integrating prior knowledge of action outcomes and sensory evidence for making decisions while maintaining prior knowledge for future actions. As outcome- and sensory-based decisions are often tested separately, it is unclear how these processes are integrated in the brain. In a tone frequency discrimination task with two sound durations and asymmetric reward blocks, we found that neurons in the medial prefrontal cortex of male mice represented the additive combination of prior reward expectations and choices. The sensory inputs and choices were selectively decoded from the auditory cortex irrespective of reward priors and the secondary motor cortex, respectively, suggesting localized computations of task variables are required within single trials. In contrast, all the recorded regions represented prior values that needed to be maintained across trials. We propose localized and global computations of task variables in different time scales in the cerebral cortex.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-48338-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48338-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-48338-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().