Gut microbiome remodeling and metabolomic profile improves in response to protein pacing with intermittent fasting versus continuous caloric restriction

Alex E. Mohr, Karen L. Sweazea, Devin A. Bowes, Paniz Jasbi, Corrie M. Whisner, Dorothy D. Sears, Rosa Krajmalnik-Brown, Yan Jin, Haiwei Gu, Judith Klein-Seetharaman, Karen M. Arciero, Eric Gumpricht and Paul J. Arciero ()
Additional contact information
Alex E. Mohr: Arizona State University
Karen L. Sweazea: Arizona State University
Devin A. Bowes: Arizona State University
Paniz Jasbi: Arizona State University
Corrie M. Whisner: Arizona State University
Dorothy D. Sears: Arizona State University
Rosa Krajmalnik-Brown: Arizona State University
Yan Jin: Florida International University
Haiwei Gu: Arizona State University
Judith Klein-Seetharaman: Arizona State University
Karen M. Arciero: Skidmore College
Eric Gumpricht: LLC
Paul J. Arciero: Skidmore College

Nature Communications, 2024, vol. 15, issue 1, 1-20

Abstract: Abstract The gut microbiome (GM) modulates body weight/composition and gastrointestinal functioning; therefore, approaches targeting resident gut microbes have attracted considerable interest. Intermittent fasting (IF) and protein pacing (P) regimens are effective in facilitating weight loss (WL) and enhancing body composition. However, the interrelationships between IF- and P-induced WL and the GM are unknown. The current randomized controlled study describes distinct fecal microbial and plasma metabolomic signatures between combined IF-P (n = 21) versus a heart-healthy, calorie-restricted (CR, n = 20) diet matched for overall energy intake in free-living human participants (women = 27; men = 14) with overweight/obesity for 8 weeks. Gut symptomatology improves and abundance of Christensenellaceae microbes and circulating cytokines and amino acid metabolites favoring fat oxidation increase with IF-P (p

Date: 2024
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DOI: 10.1038/s41467-024-48355-5

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