Cingulate microstimulation induces negative decision-making via reduced top-down influence on primate fronto-cingulo-striatal network

Satoko Amemori, Ann M. Graybiel and Ken-ichi Amemori ()
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Satoko Amemori: Kyoto University
Ann M. Graybiel: Massachusetts Institute of Technology
Ken-ichi Amemori: Kyoto University

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract The dorsolateral prefrontal cortex (dlPFC) is crucial for regulation of emotion that is known to aid prevention of depression. The broader fronto-cingulo-striatal (FCS) network, including cognitive dlPFC and limbic cingulo-striatal regions, has been associated with a negative evaluation bias often seen in depression. The mechanism by which dlPFC regulates the limbic system remains largely unclear. Here we have successfully induced a negative bias in decision-making in female primates performing a conflict decision-making task, by directly microstimulating the subgenual cingulate cortex while simultaneously recording FCS local field potentials (LFPs). The artificially induced negative bias in decision-making was associated with a significant decrease in functional connectivity from cognitive to limbic FCS regions, represented by a reduction in Granger causality in beta-range LFPs from the dlPFC to the other regions. The loss of top-down directional influence from cognitive to limbic regions, we suggest, could underlie negative biases in decision-making as observed in depressive states.

Date: 2024
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DOI: 10.1038/s41467-024-48375-1

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