E-cardiac patch to sense and repair infarcted myocardium

Renjie Qiu, Xingying Zhang, Chen Song, Kaige Xu, Huijia Nong, Yi Li, Xianglong Xing, Kibret Mequanint, Qian Liu, Quan Yuan, Xiaomin Sun, Malcolm Xing () and Leyu Wang ()
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Renjie Qiu: Southern Medical University
Xingying Zhang: University of Manitoba
Chen Song: Southern Medical University
Kaige Xu: University of Manitoba
Huijia Nong: Southern Medical University
Yi Li: Southern Medical University
Xianglong Xing: Southern Medical University
Kibret Mequanint: The University of Western Ontario
Qian Liu: University of Winnipeg
Quan Yuan: Sichuan University
Xiaomin Sun: Southern Medical University
Malcolm Xing: University of Manitoba
Leyu Wang: Southern Medical University

Nature Communications, 2024, vol. 15, issue 1, 1-20

Abstract: Abstract Conductive cardiac patches can rebuild the electroactive microenvironment for the infarcted myocardium but their repair effects benefit by carried seed cells or drugs. The key to success is the effective integration of electrical stimulation with the microenvironment created by conductive cardiac patches. Besides, due to the concerns in a high re-admission ratio of heart patients, a remote medicine device will underpin the successful repair. Herein, we report a miniature self-powered biomimetic trinity triboelectric nanogenerator with a unique double-spacer structure that unifies energy harvesting, therapeutics, and diagnosis in one cardiac patch. Trinity triboelectric nanogenerator conductive cardiac patches improve the electroactivity of the infarcted heart and can also wirelessly monitor electrocardiosignal to a mobile device for diagnosis. RNA sequencing analysis from rat hearts reveals that this trinity cardiac patches mainly regulates cardiac muscle contraction-, energy metabolism-, and vascular regulation-related mRNA expressions in vivo. The research is spawning a device that truly integrates an electrical stimulation of a functional heart patch and self-powered e-care remote diagnostic sensor.

Date: 2024
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DOI: 10.1038/s41467-024-48468-x

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