Heliorhodopsin-mediated light-modulation of ABC transporter

Shin-Gyu Cho, Ji-Hyun Kim, Ji-eun Lee, In-Jung Choi, Myungchul Song, Kimleng Chuon, Jin-gon Shim, Kun-Wook Kang and Kwang-Hwan Jung ()
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Shin-Gyu Cho: Sogang University
Ji-Hyun Kim: Sogang University
Ji-eun Lee: Sogang University
In-Jung Choi: Sogang University
Myungchul Song: Sogang University
Kimleng Chuon: Sogang University
Jin-gon Shim: Sogang University
Kun-Wook Kang: Sogang University
Kwang-Hwan Jung: Sogang University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Heliorhodopsins (HeRs) have been hypothesized to have widespread functions. Recently, the functions for few HeRs have been revealed; however, the hypothetical functions remain largely unknown. Herein, we investigate light-modulation of heterodimeric multidrug resistance ATP-binding cassette transporters (OmrDE) mediated by Omithinimicrobium cerasi HeR. In this study, we classifiy genes flanking the HeR-encoding genes and identify highly conservative residues for protein–protein interactions. Our results reveal that the interaction between OcHeR and OmrDE shows positive cooperatively sequential binding through thermodynamic parameters. Moreover, light-induced OcHeR upregulates OmrDE drug transportation. Hence, the binding may be crucial to drug resistance in O. cerasi as it survives in a drug-containing habitat. Overall, we unveil a function of HeR as regulatory rhodopsin for multidrug resistance. Our findings suggest potential applications in optogenetic technology.

Date: 2024
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DOI: 10.1038/s41467-024-48650-1

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