Cerebral microstructural alterations in Post-COVID-condition are related to cognitive impairment, olfactory dysfunction and fatigue

Jonas A. Hosp (), Marco Reisert, Andrea Dressing, Veronika Götz, Elias Kellner, Hansjörg Mast, Susan Arndt, Cornelius F. Waller, Dirk Wagner, Siegbert Rieg, Horst Urbach, Cornelius Weiller, Nils Schröter and Alexander Rau
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Jonas A. Hosp: University of Freiburg
Marco Reisert: University of Freiburg
Andrea Dressing: University of Freiburg
Veronika Götz: University of Freiburg
Elias Kellner: University of Freiburg
Hansjörg Mast: University of Freiburg
Susan Arndt: University of Freiburg
Cornelius F. Waller: University of Freiburg
Dirk Wagner: University of Freiburg
Siegbert Rieg: University of Freiburg
Horst Urbach: University of Freiburg
Cornelius Weiller: University of Freiburg
Nils Schröter: University of Freiburg
Alexander Rau: University of Freiburg

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract After contracting COVID-19, a substantial number of individuals develop a Post-COVID-Condition, marked by neurologic symptoms such as cognitive deficits, olfactory dysfunction, and fatigue. Despite this, biomarkers and pathophysiological understandings of this condition remain limited. Employing magnetic resonance imaging, we conduct a comparative analysis of cerebral microstructure among patients with Post-COVID-Condition, healthy controls, and individuals that contracted COVID-19 without long-term symptoms. We reveal widespread alterations in cerebral microstructure, attributed to a shift in volume from neuronal compartments to free fluid, associated with the severity of the initial infection. Correlating these alterations with cognition, olfaction, and fatigue unveils distinct affected networks, which are in close anatomical-functional relationship with the respective symptoms.

Date: 2024
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DOI: 10.1038/s41467-024-48651-0

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