Chronic intracranial recordings in the globus pallidus reveal circadian rhythms in Parkinson’s disease

Jackson N. Cagle, Tiberio de Araujo, Kara A. Johnson, John Yu, Lauren Fanty, Filipe P. Sarmento, Simon Little, Michael S. Okun, Joshua K. Wong and Coralie de Hemptinne ()
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Jackson N. Cagle: University of Florida
Tiberio de Araujo: University of Florida
Kara A. Johnson: University of Florida
John Yu: University of Florida
Lauren Fanty: University of Florida
Filipe P. Sarmento: University of Florida
Simon Little: University of California San Francisco
Michael S. Okun: University of Florida
Joshua K. Wong: University of Florida
Coralie de Hemptinne: University of Florida

Nature Communications, 2024, vol. 15, issue 1, 1-9

Abstract: Abstract Circadian rhythms have been shown in the subthalamic nucleus (STN) in Parkinson’s disease (PD), but only a few studies have focused on the globus pallidus internus (GPi). This retrospective study investigates GPi circadian rhythms in a large cohort of subjects with PD (130 recordings from 93 subjects) with GPi activity chronically recorded in their home environment. We found a significant change in GPi activity between daytime and nighttime in most subjects (82.4%), with a reduction in GPi activity at nighttime in 56.2% of recordings and an increase in activity in 26.2%. GPi activity in higher frequency bands ( > 20 Hz) was more likely to decrease at night and in patients taking extended-release levodopa medication. Our results suggest that circadian fluctuations in the GPi vary across individuals and that increased power at night might be due to the reemergence of pathological neural activity. These findings should be considered to ensure successful implementation of adaptive neurostimulation paradigms in the real-world.

Date: 2024
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DOI: 10.1038/s41467-024-48732-0

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