Lipidome atlas of the adult human brain

Maria Osetrova, Anna Tkachev, Waltraud Mair, Patricia Guijarro Larraz, Olga Efimova, Ilia Kurochkin, Elena Stekolshchikova, Nickolay Anikanov, Juat Chin Foo, Amaury Cazenave-Gassiot, Aleksandra Mitina, Polina Ogurtsova, Song Guo, Daria M. Potashnikova, Alexander A. Gulin, Alexander A. Vasin, Anastasia Sarycheva, Gleb Vladimirov, Maria Fedorova, Yury Kostyukevich, Evgeny Nikolaev, Markus R. Wenk (), Ekaterina E. Khrameeva () and Philipp Khaitovich ()
Additional contact information
Maria Osetrova: Skolkovo Institute of Science and Technology
Anna Tkachev: Skolkovo Institute of Science and Technology
Waltraud Mair: Skolkovo Institute of Science and Technology
Patricia Guijarro Larraz: Skolkovo Institute of Science and Technology
Olga Efimova: Skolkovo Institute of Science and Technology
Ilia Kurochkin: Skolkovo Institute of Science and Technology
Elena Stekolshchikova: Skolkovo Institute of Science and Technology
Nickolay Anikanov: Skolkovo Institute of Science and Technology
Juat Chin Foo: Yong Loo Lin School of Medicine; National University of Singapore
Amaury Cazenave-Gassiot: Yong Loo Lin School of Medicine; National University of Singapore
Aleksandra Mitina: Skolkovo Institute of Science and Technology
Polina Ogurtsova: Skolkovo Institute of Science and Technology
Song Guo: Skolkovo Institute of Science and Technology
Daria M. Potashnikova: Lomonosov Moscow State University
Alexander A. Gulin: N. N. Semenov Federal Research Center for Chemical Physics Russian Academy of Sciences
Alexander A. Vasin: N. N. Semenov Federal Research Center for Chemical Physics Russian Academy of Sciences
Anastasia Sarycheva: Skolkovo Institute of Science and Technology
Gleb Vladimirov: Skolkovo Institute of Science and Technology
Maria Fedorova: Leipzig University
Yury Kostyukevich: Skolkovo Institute of Science and Technology
Evgeny Nikolaev: Skolkovo Institute of Science and Technology
Markus R. Wenk: Yong Loo Lin School of Medicine; National University of Singapore
Ekaterina E. Khrameeva: Skolkovo Institute of Science and Technology
Philipp Khaitovich: Skolkovo Institute of Science and Technology

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affecting 93% of the 419 analyzed lipids. These differences reflect the brain’s structural characteristics, such as myelin content (345 lipids) and cell type composition (353 lipids), but also functional traits: functional connectivity (76 lipids) and information processing hierarchy (60 lipids). Combining lipid composition and mRNA expression data further enhances functional connectivity association. Biochemically, lipids linked with structural and functional brain features display distinct lipid class distribution, unsaturation extent, and prevalence of omega-3 and omega-6 fatty acid residues. We verified our conclusions by parallel analysis of three adult macaque brains, targeted analysis of 216 lipids, mass spectrometry imaging, and lipidome assessment of sorted murine neurons.

Date: 2024
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DOI: 10.1038/s41467-024-48734-y

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