Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease

Samira Salihovic, Niklas Nyström, Charlotte Bache-Wiig Mathisen, Robert Kruse, Christine Olbjørn, Svend Andersen, Alexandra J. Noble, Maria Dorn-Rasmussen, Igor Bazov, Gøri Perminow, Randi Opheim, Trond Espen Detlie, Gert Huppertz-Hauss, Charlotte R. H. Hedin, Marie Carlson, Lena Öhman, Maria K. Magnusson, Åsa V. Keita, Johan D. Söderholm, Mauro D’Amato, Matej Orešič, Vibeke Wewer, Jack Satsangi, Carl Mårten Lindqvist, Johan Burisch, Holm H. Uhlig, Dirk Repsilber, Tuulia Hyötyläinen, Marte Lie Høivik and Jonas Halfvarson ()
Additional contact information
Samira Salihovic: Faculty of Medicine and Health, Örebro University
Niklas Nyström: Uppsala University
Charlotte Bache-Wiig Mathisen: Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo
Robert Kruse: Faculty of Medicine and Health, Örebro University
Christine Olbjørn: Akershus University Hospital
Svend Andersen: Vestfold Hospital Trust
Alexandra J. Noble: University of Oxford
Maria Dorn-Rasmussen: Copenhagen University Hospital - Amager and Hvidovre
Igor Bazov: Faculty of Medicine and Health, Örebro University
Gøri Perminow: Oslo University Hospital
Randi Opheim: Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo
Trond Espen Detlie: Akershus University Hospital, Lørenskog, Norway and Faculty of Medicine, University of Oslo
Gert Huppertz-Hauss: Telemark Hospital Trust
Charlotte R. H. Hedin: Department of Medicine Solna
Marie Carlson: Uppsala University
Lena Öhman: Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Maria K. Magnusson: Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Åsa V. Keita: Linköping University
Johan D. Söderholm: Linköping University
Mauro D’Amato: Basque Foundation for Science
Matej Orešič: Faculty of Medicine and Health, Örebro University
Vibeke Wewer: Copenhagen University Hospital - Amager and Hvidovre
Jack Satsangi: University of Oxford
Carl Mårten Lindqvist: Faculty of Medicine and Health, Örebro University
Johan Burisch: Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre
Holm H. Uhlig: University of Oxford
Dirk Repsilber: Faculty of Medicine and Health, Örebro University
Tuulia Hyötyläinen: Örebro University
Marte Lie Høivik: Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo
Jonas Halfvarson: Faculty of Medicine and Health, Örebro University

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.

Date: 2024
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DOI: 10.1038/s41467-024-48763-7

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