Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)

Eliah G. Overbey, Krista Ryon, JangKeun Kim, Braden T. Tierney, Remi Klotz, Veronica Ortiz, Sean Mullane, Julian C. Schmidt, Matthew MacKay, Namita Damle, Deena Najjar, Irina Matei, Laura Patras, J. Sebastian Garcia Medina, Ashley S. Kleinman, Jeremy Wain Hirschberg, Jacqueline Proszynski, S. Anand Narayanan, Caleb M. Schmidt, Evan E. Afshin, Lucinda Innes, Mateo Mejia Saldarriaga, Michael A. Schmidt, Richard D. Granstein, Bader Shirah, Min Yu, David Lyden, Jaime Mateus and Christopher E. Mason ()
Additional contact information
Eliah G. Overbey: Cornell University
Krista Ryon: Cornell University
JangKeun Kim: Cornell University
Braden T. Tierney: Cornell University
Remi Klotz: University of Southern California
Veronica Ortiz: University of Southern California
Sean Mullane: Space Exploration Technologies Corporation
Julian C. Schmidt: Boulder
Matthew MacKay: Cornell University
Namita Damle: Cornell University
Deena Najjar: Cornell University
Irina Matei: Weill Cornell Medicine
Laura Patras: Weill Cornell Medicine
J. Sebastian Garcia Medina: Cornell University
Ashley S. Kleinman: Cornell University
Jeremy Wain Hirschberg: Cornell University
Jacqueline Proszynski: Cornell University
S. Anand Narayanan: Florida State University, College of Education, Health, and Human Sciences, Department of Health, Nutrition, and Food Sciences
Caleb M. Schmidt: Boulder
Evan E. Afshin: Cornell University
Lucinda Innes: Cornell University
Mateo Mejia Saldarriaga: Weill Cornell Medicine
Michael A. Schmidt: Boulder
Richard D. Granstein: Weill Cornell Medicine
Bader Shirah: King Faisal Specialist Hospital & Research Centre
Min Yu: University of Southern California
David Lyden: Weill Cornell Medicine
Jaime Mateus: Space Exploration Technologies Corporation
Christopher E. Mason: Cornell University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact of spaceflight on the human body. Biospecimen samples were collected from four crew members longitudinally before (Launch: L-92, L-44, L-3 days), during (Flight Day: FD1, FD2, FD3), and after (Return: R + 1, R + 45, R + 82, R + 194 days) spaceflight, spanning a total of 289 days across 2021-2022. The collection process included venous whole blood, capillary dried blood spot cards, saliva, urine, stool, body swabs, capsule swabs, SpaceX Dragon capsule HEPA filter, and skin biopsies. Venous whole blood was further processed to obtain aliquots of serum, plasma, extracellular vesicles and particles, and peripheral blood mononuclear cells. In total, 2,911 sample aliquots were shipped to our central lab at Weill Cornell Medicine for downstream assays and biobanking. This paper provides an overview of the extensive biospecimen collection and highlights their processing procedures and long-term biobanking techniques, facilitating future molecular tests and evaluations.As such, this study details a robust framework for obtaining and preserving high-quality human, microbial, and environmental samples for aerospace medicine in the Space Omics and Medical Atlas (SOMA) initiative, which can aid future human spaceflight and space biology experiments.

Date: 2024
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DOI: 10.1038/s41467-024-48806-z

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