Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes

Josh G. Chenoweth (), Carlo Colantuoni, Deborah A. Striegel, Pavol Genzor, Joost Brandsma, Paul W. Blair, Subramaniam Krishnan, Elizabeth Chiyka, Mehran Fazli, Rittal Mehta, Michael Considine, Leslie Cope, Audrey C. Knight, Anissa Elayadi, Anne Fox, Ronna Hertzano, Andrew G. Letizia, Alex Owusu-Ofori, Isaac Boakye, Albert A. Aduboffour, Daniel Ansong, Eno Biney, George Oduro, Kevin L. Schully and Danielle V. Clark
Additional contact information
Josh G. Chenoweth: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Carlo Colantuoni: Johns Hopkins School of Medicine
Deborah A. Striegel: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Pavol Genzor: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Joost Brandsma: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Paul W. Blair: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Subramaniam Krishnan: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Elizabeth Chiyka: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Mehran Fazli: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Rittal Mehta: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Michael Considine: Johns Hopkins University
Leslie Cope: Johns Hopkins University
Audrey C. Knight: Johns Hopkins School of Medicine
Anissa Elayadi: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Anne Fox: Naval Medical Research Unit EURAFCENT Ghana detachment
Ronna Hertzano: National Institutes of Health
Andrew G. Letizia: Naval Medical Research Unit EURAFCENT Ghana detachment
Alex Owusu-Ofori: Komfo Anokye Teaching Hospital (KATH)
Isaac Boakye: KATH
Albert A. Aduboffour: Komfo Anokye Teaching Hospital (KATH)
Daniel Ansong: KATH
Eno Biney: KATH
George Oduro: KATH
Kevin L. Schully: Naval Medical Research Command-Frederick
Danielle V. Clark: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There is a critical lack of data from low- and middle-income countries where the sepsis burden is increased which inhibits generalized strategies for therapeutic intervention. Here we perform RNA sequencing of whole blood to investigate longitudinal host response to sepsis in a Ghanaian cohort. Data dimensional reduction reveals dynamic gene expression patterns that describe cell type-specific molecular phenotypes including a dysregulated myeloid compartment shared between sepsis and COVID-19. The gene expression signatures reported here define a landscape of host response to sepsis that supports interventions via targeting immunophenotypes to improve outcomes.

Date: 2024
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DOI: 10.1038/s41467-024-48821-0

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