Claustrum neurons projecting to the anterior cingulate restrict engagement during sleep and behavior

Gal Atlan, Noa Matosevich, Noa Peretz-Rivlin, Idit Marsh-Yvgi, Noam Zelinger, Eden Chen, Timna Kleinman, Noa Bleistein, Efrat Sheinbach, Maya Groysman, Yuval Nir and Ami Citri ()
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Gal Atlan: The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram
Noa Matosevich: Faculty of Medical and Health Sciences, Tel Aviv University
Noa Peretz-Rivlin: The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram
Idit Marsh-Yvgi: The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram
Noam Zelinger: Faculty of Medical and Health Sciences, Tel Aviv University
Eden Chen: The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram
Timna Kleinman: The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram
Noa Bleistein: The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram
Efrat Sheinbach: The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram
Maya Groysman: The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram
Yuval Nir: Faculty of Medical and Health Sciences, Tel Aviv University
Ami Citri: The Hebrew University of Jerusalem; Edmond J. Safra Campus, Givat Ram

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract The claustrum has been linked to attention and sleep. We hypothesized that this reflects a shared function, determining responsiveness to stimuli, which spans the axis of engagement. To test this hypothesis, we recorded claustrum population dynamics from male mice during both sleep and an attentional task (‘ENGAGE’). Heightened activity in claustrum neurons projecting to the anterior cingulate cortex (ACCp) corresponded to reduced sensory responsiveness during sleep. Similarly, in the ENGAGE task, heightened ACCp activity correlated with disengagement and behavioral lapses, while low ACCp activity correlated with hyper-engagement and impulsive errors. Chemogenetic elevation of ACCp activity reduced both awakenings during sleep and impulsive errors in the ENGAGE task. Furthermore, mice employing an exploration strategy in the task showed a stronger correlation between ACCp activity and performance compared to mice employing an exploitation strategy which reduced task complexity. Our results implicate ACCp claustrum neurons in restricting engagement during sleep and goal-directed behavior.

Date: 2024
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DOI: 10.1038/s41467-024-48829-6

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