Cobalt-catalyzed cross-electrophile coupling of alkynyl sulfides with unactivated chlorosilanes

Donghui Xing, Jinlin Liu, Dingxin Cai, Bin Huang, Huanfeng Jiang and Liangbin Huang ()
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Donghui Xing: South China University of Technology
Jinlin Liu: South China University of Technology
Dingxin Cai: South China University of Technology
Bin Huang: South China University of Technology
Huanfeng Jiang: South China University of Technology
Liangbin Huang: South China University of Technology

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Herein, we disclose a highly efficient cobalt-catalyzed cross-electrophile alkynylation of a broad range of unactivated chlorosilanes with alkynyl sulfides as a stable and practical alkynyl electrophiles. Strategically, employing easily synthesized alkynyl sulfides as alkynyl precursors allows access to various alkynylsilanes in good to excellent yields. Notably, this method avoids the utilization of strong bases, noble metal catalysts, high temperature and forcing reaction conditions, thus presenting apparent advantages, such as broad substrate scope (72 examples, up to 97% yield), high Csp-S chemo-selectivity and excellent functional group compatibility (Ar-X, X = Cl, Br, I, OTf, OTs). Moreover, the utilities of this method are also illustrated by downstream transformations and late-stage modification of structurally complex natural products and pharmaceuticals. Mechanistic studies elucidated that the cobalt catalyst initially reacted with alkynyl sulfides, and the activation of chlorosilanes occurred via an SN2 process instead of a radical pathway.

Date: 2024
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DOI: 10.1038/s41467-024-48873-2

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