A shape-driven reentrant jamming transition in confluent monolayers of synthetic cell-mimics

Pragya Arora (), Souvik Sadhukhan, Saroj Kumar Nandi, Dapeng Bi, A. K. Sood and Rajesh Ganapathy ()
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Pragya Arora: Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur
Souvik Sadhukhan: Tata Institute of Fundamental Research
Saroj Kumar Nandi: Tata Institute of Fundamental Research
Dapeng Bi: Northeastern University
A. K. Sood: Indian Institute of Science
Rajesh Ganapathy: Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Many critical biological processes, like wound healing, require densely packed cell monolayers/tissues to transition from a jammed solid-like to a fluid-like state. Although numerical studies anticipate changes in the cell shape alone can lead to unjamming, experimental support for this prediction is not definitive because, in living systems, fluidization due to density changes cannot be ruled out. Additionally, a cell’s ability to modulate its motility only compounds difficulties since even in assemblies of rigid active particles, changing the nature of self-propulsion has non-trivial effects on the dynamics. Here, we design and assemble a monolayer of synthetic cell-mimics and examine their collective behaviour. By systematically increasing the persistence time of self-propulsion, we discovered a cell shape-driven, density-independent, re-entrant jamming transition. Notably, we observed cell shape and shape variability were mutually constrained in the confluent limit and followed the same universal scaling as that observed in confluent epithelia. Dynamical heterogeneities, however, did not conform to this scaling, with the fast cells showing suppressed shape variability, which our simulations revealed is due to a transient confinement effect of these cells by their slower neighbors. Our experiments unequivocally establish a morphodynamic link, demonstrating that geometric constraints alone can dictate epithelial jamming/unjamming.

Date: 2024
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DOI: 10.1038/s41467-024-49044-z

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