Faecal microbiota of schoolchildren is associated with nutritional status and markers of inflammation: a double-blinded cluster-randomized controlled trial using multi-micronutrient fortified rice

Yohannes Seyoum, Valérie Greffeuille, Dorgeles Kouakou Dje Kouadio, Khov Kuong, Williams Turpin, Rachida M’Rabt, Vincent Chochois, Sonia Fortin, Marlène Perignon, Marion Fiorentino, Jacques Berger, Kurt Burja, Maiza Campos Ponce, Chhoun Chamnan, Frank T. Wieringa and Christèle Humblot ()
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Yohannes Seyoum: Université de La Réunion
Valérie Greffeuille: Université de La Réunion
Dorgeles Kouakou Dje Kouadio: Université de La Réunion
Khov Kuong: Ministry of Agriculture, Forestry and Fisheries
Williams Turpin: Université de La Réunion
Rachida M’Rabt: Université de La Réunion
Vincent Chochois: Université de La Réunion
Sonia Fortin: Université de La Réunion
Marlène Perignon: Université de La Réunion
Marion Fiorentino: Université de La Réunion
Jacques Berger: Université de La Réunion
Kurt Burja: United Nations World Food Programme
Maiza Campos Ponce: VU University Amsterdam
Chhoun Chamnan: Ministry of Agriculture, Forestry and Fisheries
Frank T. Wieringa: Université de La Réunion
Christèle Humblot: Université de La Réunion

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Faecal microbiota plays a critical role in human health, but its relationship with nutritional status among schoolchildren remains under-explored. Here, in a double-blinded cluster-randomized controlled trial on 380 Cambodian schoolchildren, we characterize the impact of six months consumption of two types of rice fortified with different levels of vitamins and minerals on pre-specified outcomes. We investigate the association between the faecal microbiota (16SrRNA sequencing) and age, sex, nutritional status (underweight, stunting), micronutrient status (iron, zinc and vitamin A deficiencies, anaemia, iron deficient anaemia, hemoglobinopathy), inflammation (systemic, gut), and parasitic infection. We show that the faecal microbiota is characterised by a surprisingly high proportion of Lactobacillaceae. We discover that deficiencies in specific micronutrients, such as iron and vitamin A, correlate with particular microbiota profiles, whereas zinc deficiency shows no such association. The nutritional intervention with the two rice treatments impacts both the composition and functions predicted from compositional analysis in different ways. (ClinicalTrials.gov (Identifier: NCT01706419))

Date: 2024
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DOI: 10.1038/s41467-024-49093-4

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