Ferroptosis induction in host rice by endophyte OsiSh-2 is necessary for mutualism and disease resistance in symbiosis

Xianqiu Xiong, Jing Zeng, Qing Ning, Heqin Liu, Zhigang Bu, Xuan Zhang, Jiarui Zeng, Rui Zhuo, Kunpeng Cui, Ziwei Qin, Yan Gao (), Xuanming Liu () and Yonghua Zhu ()
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Xianqiu Xiong: Hunan University
Jing Zeng: Hunan University
Qing Ning: Hunan University
Heqin Liu: Hunan University
Zhigang Bu: Hunan University
Xuan Zhang: Hunan University
Jiarui Zeng: Hunan University
Rui Zhuo: Hunan University
Kunpeng Cui: Hunan University
Ziwei Qin: Hunan University
Yan Gao: Hunan University
Xuanming Liu: Hunan University
Yonghua Zhu: Hunan University

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Ferroptosis is an iron-dependent cell death that was discovered recently. For beneficial microbes to establish mutualistic relationships with hosts, precisely controlled cell death in plant cells is necessary. However, whether ferroptosis is involved in the endophyte‒plant system is poorly understood. Here, we reported that endophytic Streptomyces hygroscopicus OsiSh-2, which established a sophisticated and beneficial interaction with host rice plants, caused ferroptotic cell death in rice characterized by ferroptosis- and immune-related markers. Treatments with ferroptosis inhibitors and inducers, different doses of OsiSh-2, and the siderophore synthesis-deficient mutant ΔcchH revealed that only moderate ferroptosis induced by endophytes is essential for the establishment of an optimal symbiont to enhance plant growth. Additionally, ferroptosis involved in a defence-primed state in rice, which contributed to improved resistance against rice blast disease. Overall, our study provides new insights into the mechanisms of endophyte‒plant interactions mediated by ferroptosis and suggests new directions for crop yield promotion.

Date: 2024
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DOI: 10.1038/s41467-024-49099-y

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