Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study

Diana Dunca (), Sandesh Chopade, María Gordillo-Marañón, Aroon D. Hingorani, Karoline Kuchenbaecker, Chris Finan and Amand F. Schmidt
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Diana Dunca: University College London
Sandesh Chopade: University College London
María Gordillo-Marañón: University College London
Aroon D. Hingorani: University College London
Karoline Kuchenbaecker: University College London
Chris Finan: University College London
Amand F. Schmidt: University College London

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract CETP inhibitors are a class of lipid-lowering drugs in development for treatment of coronary heart disease (CHD). Genetic studies in East Asian ancestry have interpreted the lack of CETP signal with low-density lipoprotein cholesterol (LDL-C) and lack of drug target Mendelian randomization (MR) effect on CHD as evidence that CETP inhibitors might not be effective in East Asian participants. Capitalizing on recent increases in sample size of East Asian genetic studies, we conducted a drug target MR analysis, scaled to a standard deviation increase in high-density lipoprotein cholesterol. Despite finding evidence for possible neutral effects of lower CETP levels on LDL-C, systolic blood pressure and pulse pressure in East Asians (interaction p-values

Date: 2024
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DOI: 10.1038/s41467-024-49109-z

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