Wnt-Ror-Dvl signalling and the dystrophin complex organize planar-polarized membrane compartments in C. elegans muscles

Alice Peysson, Noura Zariohi, Marie Gendrel, Amandine Chambert-Loir, Noémie Frébault, Elise Cheynet, Olga Andrini and Thomas Boulin ()
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Alice Peysson: MeLiS
Noura Zariohi: MeLiS
Marie Gendrel: Université Paris Sciences et Lettres Research University
Amandine Chambert-Loir: MeLiS
Noémie Frébault: MeLiS
Elise Cheynet: MeLiS
Olga Andrini: MeLiS
Thomas Boulin: MeLiS

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Cell polarity mechanisms allow the formation of specialized membrane domains with unique protein compositions, signalling properties, and functional characteristics. By analyzing the localization of potassium channels and proteins belonging to the dystrophin-associated protein complex, we reveal the existence of distinct planar-polarized membrane compartments at the surface of C. elegans muscle cells. We find that muscle polarity is controlled by a non-canonical Wnt signalling cascade involving the ligand EGL-20/Wnt, the receptor CAM-1/Ror, and the intracellular effector DSH-1/Dishevelled. Interestingly, classical planar cell polarity proteins are not required for this process. Using time-resolved protein degradation, we demonstrate that –while it is essentially in place by the end of embryogenesis– muscle polarity is a dynamic state, requiring continued presence of DSH-1 throughout post-embryonic life. Our results reveal the unsuspected complexity of the C. elegans muscle membrane and establish a genetically tractable model system to study cellular polarity and membrane compartmentalization in vivo.

Date: 2024
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DOI: 10.1038/s41467-024-49154-8

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