The association of maternal factors with the neonatal microbiota and health

Bin Zhu, David J. Edwards, Katherine M. Spaine, Laahirie Edupuganti, Andrey Matveyev, Myrna G. Serrano and Gregory A. Buck ()
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Bin Zhu: Virginia Commonwealth University
David J. Edwards: Virginia Commonwealth University
Katherine M. Spaine: Virginia Commonwealth University
Laahirie Edupuganti: Virginia Commonwealth University
Andrey Matveyev: Virginia Commonwealth University
Myrna G. Serrano: Virginia Commonwealth University
Gregory A. Buck: Virginia Commonwealth University

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract The human microbiome plays a crucial role in human health. However, the influence of maternal factors on the neonatal microbiota remains obscure. Herein, our observations suggest that the neonatal microbiotas, particularly the buccal microbiota, change rapidly within 24–48 h of birth but begin to stabilize by 48–72 h after parturition. Network analysis clustered over 200 maternal factors into thirteen distinct groups, and most associated factors were in the same group. Multiple maternal factor groups were associated with the neonatal buccal, rectal, and stool microbiotas. Particularly, a higher maternal inflammatory state and a lower maternal socioeconomic position were associated with a higher alpha diversity of the neonatal buccal microbiota and beta diversity of the neonatal stool microbiota was influenced by maternal diet and cesarean section by 24–72 h postpartum. The risk of admission of a neonate to the newborn intensive care unit was associated with preterm birth as well as higher cytokine levels and probably higher alpha diversity of the maternal buccal microbiota.

Date: 2024
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DOI: 10.1038/s41467-024-49160-w

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