A biodegradable and flexible neural interface for transdermal optoelectronic modulation and regeneration of peripheral nerves

Pengcheng Sun, Chaochao Li, Can Yang, Mengchun Sun, Hanqing Hou, Yanjun Guan, Jinger Chen, Shangbin Liu, Kuntao Chen, Yuan Ma, Yunxiang Huang, Xiangling Li, Huachun Wang, Liu Wang, Shengfeng Chen, Haofeng Cheng, Wei Xiong, Xing Sheng, Milin Zhang, Jiang Peng, Shirong Wang (), Yu Wang () and Lan Yin ()
Additional contact information
Pengcheng Sun: Tsinghua University
Chaochao Li: Key Laboratory of Musculoskeletal Trauma and Injuries PLA
Can Yang: Tsinghua University
Mengchun Sun: Key Laboratory of Musculoskeletal Trauma and Injuries PLA
Hanqing Hou: Tsinghua University
Yanjun Guan: Key Laboratory of Musculoskeletal Trauma and Injuries PLA
Jinger Chen: Tsinghua University
Shangbin Liu: Tsinghua University
Kuntao Chen: Tsinghua University
Yuan Ma: Tsinghua University
Yunxiang Huang: Dartmouth College
Xiangling Li: Key Laboratory of Musculoskeletal Trauma and Injuries PLA
Huachun Wang: Shenzhen Campus of Sun Yat-sen University
Liu Wang: Beihang University
Shengfeng Chen: Key Laboratory of Musculoskeletal Trauma and Injuries PLA
Haofeng Cheng: Key Laboratory of Musculoskeletal Trauma and Injuries PLA
Wei Xiong: Chinese Institute for Brain Research
Xing Sheng: Tsinghua University
Milin Zhang: Tsinghua University
Jiang Peng: Key Laboratory of Musculoskeletal Trauma and Injuries PLA
Shirong Wang: MegaRobo Technologies Co. ltd
Yu Wang: Key Laboratory of Musculoskeletal Trauma and Injuries PLA
Lan Yin: Tsinghua University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Optoelectronic neural interfaces can leverage the photovoltaic effect to convert light into electrical current, inducing charge redistribution and enabling nerve stimulation. This method offers a non-genetic and remote approach for neuromodulation. Developing biodegradable and efficient optoelectronic neural interfaces is important for achieving transdermal stimulation while minimizing infection risks associated with device retrieval, thereby maximizing therapeutic outcomes. We propose a biodegradable, flexible, and miniaturized silicon-based neural interface capable of transdermal optoelectronic stimulation for neural modulation and nerve regeneration. Enhancing the device interface with thin-film molybdenum significantly improves the efficacy of neural stimulation. Our study demonstrates successful activation of the sciatic nerve in rodents and the facial nerve in rabbits. Moreover, transdermal optoelectronic stimulation accelerates the functional recovery of injured facial nerves.

Date: 2024
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DOI: 10.1038/s41467-024-49166-4

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