Sororin is an evolutionary conserved antagonist of WAPL

Ignacio Prusén Mota, Marta Galova, Alexander Schleiffer, Tan-Trung Nguyen, Ines Kovacikova, Carolina Farias Saad, Gabriele Litos, Tomoko Nishiyama, Juraj Gregan (), Jan-Michael Peters () and Peter Schlögelhofer ()
Additional contact information
Ignacio Prusén Mota: Vienna Biocenter Campus (VBC)
Marta Galova: Vienna Biocenter (VBC)
Alexander Schleiffer: Vienna Biocenter (VBC)
Tan-Trung Nguyen: Vienna Biocenter Campus (VBC)
Ines Kovacikova: Department of Chromosome Biology
Carolina Farias Saad: Vienna Biocenter Campus (VBC)
Gabriele Litos: Vienna Biocenter (VBC)
Tomoko Nishiyama: Vienna Biocenter (VBC)
Juraj Gregan: Department of Chromosome Biology
Jan-Michael Peters: Vienna Biocenter (VBC)
Peter Schlögelhofer: Vienna Biocenter Campus (VBC)

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Cohesin mediates sister chromatid cohesion to enable chromosome segregation and DNA damage repair. To perform these functions, cohesin needs to be protected from WAPL, which otherwise releases cohesin from DNA. It has been proposed that cohesin is protected from WAPL by SORORIN. However, in vivo evidence for this antagonism is missing and SORORIN is only known to exist in vertebrates and insects. It is therefore unknown how important and widespread SORORIN’s functions are. Here we report the identification of SORORIN orthologs in Schizosaccharomyces pombe (Sor1) and Arabidopsis thaliana (AtSORORIN). sor1Δ mutants display cohesion defects, which are partially alleviated by wpl1Δ. Atsororin mutant plants display dwarfism, tissue specific cohesion defects and chromosome mis-segregation. Furthermore, Atsororin mutant plants are sterile and separate sister chromatids prematurely at anaphase I. The somatic, but not the meiotic deficiencies can be alleviated by loss of WAPL. These results provide in vivo evidence for SORORIN antagonizing WAPL, reveal that SORORIN is present in organisms beyond the animal kingdom and indicate that it has acquired tissue specific functions in plants.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-49178-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49178-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-49178-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().