Supramolecular assembly activated single-molecule phosphorescence resonance energy transfer for near-infrared targeted cell imaging

Xiaolu Zhou, Xue Bai, Fangjian Shang, Heng-Yi Zhang, Li-Hua Wang, Xiufang Xu and Yu Liu ()
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Xiaolu Zhou: Nankai University
Xue Bai: Nankai University
Fangjian Shang: Nankai University
Heng-Yi Zhang: Nankai University
Li-Hua Wang: Nankai University
Xiufang Xu: Nankai University
Yu Liu: Nankai University

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Pure organic phosphorescence resonance energy transfer is a research hotspot. Herein, a single-molecule phosphorescence resonance energy transfer system with a large Stokes shift of 367 nm and near-infrared emission is constructed by guest molecule alkyl-bridged methoxy-tetraphenylethylene-phenylpyridines derivative, cucurbit[n]uril (n = 7, 8) and β-cyclodextrin modified hyaluronic acid. The high binding affinity of cucurbituril to guest molecules in various stoichiometric ratios not only regulates the topological morphology of supramolecular assembly but also induces different phosphorescence emissions. Varying from the spherical nanoparticles and nanorods for binary assemblies, three-dimensional nanoplate is obtained by the ternary co-assembly of guest with cucurbit[7]uril/cucurbit[8]uril, accompanying enhanced phosphorescence at 540 nm. Uncommonly, the secondary assembly of β-cyclodextrin modified hyaluronic acid and ternary assembly activates a single intramolecular phosphorescence resonance energy transfer process derived from phenyl pyridines unit to methoxy-tetraphenylethylene function group, enabling a near-infrared delayed fluorescence at 700 nm, which ultimately applied to mitochondrial targeted imaging for cancer cells.

Date: 2024
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DOI: 10.1038/s41467-024-49238-5

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