Pm57 from Aegilops searsii encodes a tandem kinase protein and confers wheat powdery mildew resistance

Yue Zhao, Zhenjie Dong, Jingnan Miao, Qianwen Liu, Chao Ma, Xiubin Tian, Jinqiu He, Huihui Bi, Wen Yao, Tao Li, Harsimardeep S. Gill, Zhibin Zhang, Aizhong Cao, Bao Liu, Huanhuan Li (), Sunish K. Sehgal () and Wenxuan Liu ()
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Yue Zhao: Henan Agricultural University
Zhenjie Dong: Nanjing Agricultural University
Jingnan Miao: Henan Agricultural University
Qianwen Liu: Henan Agricultural University
Chao Ma: Henan Agricultural University
Xiubin Tian: Henan Agricultural University
Jinqiu He: Henan Agricultural University
Huihui Bi: Henan Agricultural University
Wen Yao: Henan Agricultural University
Tao Li: Henan Agricultural University
Harsimardeep S. Gill: South Dakota State University
Zhibin Zhang: Northeast Normal University
Aizhong Cao: Nanjing Agricultural University
Bao Liu: Northeast Normal University
Huanhuan Li: Henan Agricultural University
Sunish K. Sehgal: South Dakota State University
Wenxuan Liu: Henan Agricultural University

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Powdery mildew is a devastating disease that affects wheat yield and quality. Wheat wild relatives represent valuable sources of disease resistance genes. Cloning and characterization of these genes will facilitate their incorporation into wheat breeding programs. Here, we report the cloning of Pm57, a wheat powdery mildew resistance gene from Aegilops searsii. It encodes a tandem kinase protein with putative kinase-pseudokinase domains followed by a von Willebrand factor A domain (WTK-vWA), being ortholog of Lr9 that mediates wheat leaf rust resistance. The resistance function of Pm57 is validated via independent mutants, gene silencing, and transgenic assays. Stable Pm57 transgenic wheat lines and introgression lines exhibit high levels of all-stage resistance to diverse isolates of the Bgt fungus, and no negative impacts on agronomic parameters are observed in our experimental set-up. Our findings highlight the emerging role of kinase fusion proteins in plant disease resistance and provide a valuable gene for wheat breeding.

Date: 2024
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DOI: 10.1038/s41467-024-49257-2

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