Spatiotemporal expression and control of haemoglobin in space

Josef Borg, Conor Loy, JangKeun Kim, Alfred Buhagiar, Christopher Chin, Namita Damle, Iwijn De Vlaminck, Alex Felice, Tammy Liu, Irina Matei, Cem Meydan, Masafumi Muratani, Omary Mzava, Eliah Overbey, Krista A. Ryon, Scott M. Smith, Braden T. Tierney, Guy Trudel, Sara R. Zwart, Afshin Beheshti (), Christopher E. Mason () and Joseph Borg ()
Additional contact information
Josef Borg: University of Malta
Conor Loy: Weill Cornell Medicine
JangKeun Kim: Weill Cornell Medicine
Alfred Buhagiar: University of Malta
Christopher Chin: Weill Cornell Medicine
Namita Damle: Weill Cornell Medicine
Iwijn De Vlaminck: Weill Cornell Medicine
Alex Felice: University of Malta
Tammy Liu: Department of Medicine
Irina Matei: Weill Cornell Medicine
Cem Meydan: Weill Cornell Medicine
Masafumi Muratani: University of Tsukuba
Omary Mzava: Cornell University
Eliah Overbey: Weill Cornell Medicine
Krista A. Ryon: Weill Cornell Medicine
Scott M. Smith: NASA Johnson Space Center
Braden T. Tierney: Weill Cornell Medicine
Guy Trudel: Department of Medicine
Sara R. Zwart: NASA Johnson Space Center
Afshin Beheshti: NASA Ames Research Center
Christopher E. Mason: Weill Cornell Medicine
Joseph Borg: University of Malta

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract It is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homeostasis and erythropoiesis, with a particular emphasis on those involved in globin chain production. Haemoglobin biology provides an intriguing model for studying space omics, as it has been extensively explored at multiple -omic levels, spanning DNA, RNA, and protein analyses, in both experimental and clinical contexts. In this study, we examined the developmental expression of haemoglobin over time and space using a unique suite of multi-omic datasets available on NASA GeneLab, from the NASA Twins Study, the JAXA CFE study, and the Inspiration4 mission. Our findings reveal significant variations in globin gene expression corresponding to the distinct spatiotemporal characteristics of the collected samples. This study sheds light on the dynamic nature of globin gene regulation in response to the space environment and provides valuable insights into the broader implications of space omics research.

Date: 2024
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DOI: 10.1038/s41467-024-49289-8

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