LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy

Ningning Wang, Andres Merits, Michael Veit, Laura Sandra Lello, Shuhan Kong, Houqi Jiao, Jie Chen, Yu Wang, Georgi Dobrikov, Félix A. Rey and Shuo Su ()
Additional contact information
Ningning Wang: Nanjing Agricultural University
Andres Merits: University of Tartu
Michael Veit: Free University Berlin
Laura Sandra Lello: University of Tartu
Shuhan Kong: Nanjing Agricultural University
Houqi Jiao: Nanjing Agricultural University
Jie Chen: Nanjing Agricultural University
Yu Wang: Nanjing Agricultural University
Georgi Dobrikov: Bulgarian Academy of Sciences
Félix A. Rey: CNRS UMR 3569, 25-28 Rue du Docteur Roux, 75724 Paris Cedex 15
Shuo Su: Nanjing Agricultural University

Nature Communications, 2024, vol. 15, issue 1, 1-7

Abstract: Abstract Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes of multiple alphaviruses to understand their ability to infect a wide range of hosts. We further discuss the challenges associated with the development of broad-spectrum treatment strategies against a diverse range of alphaviruses.

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49301-1

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DOI: 10.1038/s41467-024-49301-1

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