Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis

Julia Krämer (), Carolin Balloff, Margit Weise, Valeria Koska, Yannik Uthmeier, Isabell Esderts, Mai Nguyen-Minh, Moritz Zimmerhof, Alex Hartmann, Michael Dietrich, Jens Ingwersen, John-Ih Lee, Joachim Havla, Tania Kümpfel, Martin Kerschensteiner, Vivien Häußler, Christoph Heesen, Jan-Patrick Stellmann, Hanna G. Zimmermann, Frederike C. Oertel, Marius Ringelstein, Alexander U. Brandt, Friedemann Paul, Orhan Aktas, Hans-Peter Hartung, Heinz Wiendl, Sven G. Meuth and Philipp Albrecht ()
Additional contact information
Julia Krämer: University Hospital Münster
Carolin Balloff: Heinrich-Heine-University Düsseldorf
Margit Weise: Heinrich-Heine-University Düsseldorf
Valeria Koska: Heinrich-Heine-University Düsseldorf
Yannik Uthmeier: Heinrich-Heine-University Düsseldorf
Isabell Esderts: University Hospital Münster
Mai Nguyen-Minh: University Hospital Münster
Moritz Zimmerhof: University Hospital Münster
Alex Hartmann: Hanseatic Statistics
Michael Dietrich: Heinrich-Heine-University Düsseldorf
Jens Ingwersen: Heinrich-Heine-University Düsseldorf
John-Ih Lee: Heinrich-Heine-University Düsseldorf
Joachim Havla: Ludwig-Maximilians University München
Tania Kümpfel: Ludwig-Maximilians University München
Martin Kerschensteiner: Ludwig-Maximilians University München
Vivien Häußler: University Hospital Hamburg-Eppendorf
Christoph Heesen: University Hospital Hamburg-Eppendorf
Jan-Patrick Stellmann: University Hospital Hamburg-Eppendorf
Hanna G. Zimmermann: corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
Frederike C. Oertel: corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
Marius Ringelstein: Heinrich-Heine-University Düsseldorf
Alexander U. Brandt: corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
Friedemann Paul: corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
Orhan Aktas: Heinrich-Heine-University Düsseldorf
Hans-Peter Hartung: Heinrich-Heine-University Düsseldorf
Heinz Wiendl: University Hospital Münster
Sven G. Meuth: Heinrich-Heine-University Düsseldorf
Philipp Albrecht: Heinrich-Heine-University Düsseldorf

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Retinal optical coherence tomography has been identified as biomarker for disease progression in relapsing-remitting multiple sclerosis (RRMS), while the dynamics of retinal atrophy in progressive MS are less clear. We investigated retinal layer thickness changes in RRMS, primary and secondary progressive MS (PPMS, SPMS), and their prognostic value for disease activity. Here, we analyzed 2651 OCT measurements of 195 RRMS, 87 SPMS, 125 PPMS patients, and 98 controls from five German MS centers after quality control. Peripapillary and macular retinal nerve fiber layer (pRNFL, mRNFL) thickness predicted future relapses in all MS and RRMS patients while mRNFL and ganglion cell-inner plexiform layer (GCIPL) thickness predicted future MRI activity in RRMS (mRNFL, GCIPL) and PPMS (GCIPL). mRNFL thickness predicted future disability progression in PPMS. However, thickness change rates were subject to considerable amounts of measurement variability. In conclusion, retinal degeneration, most pronounced of pRNFL and GCIPL, occurs in all subtypes. Using the current state of technology, longitudinal assessments of retinal thickness may not be suitable on a single patient level.

Date: 2024
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DOI: 10.1038/s41467-024-49309-7

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