International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe

Mabel Budia-Silva, Tomislav Kostyanev, Stefany Ayala-Montaño, Jose Bravo-Ferrer Acosta, Maria Garcia-Castillo, Rafael Cantón, Herman Goossens, Jesus Rodriguez-Baño, Hajo Grundmann and Sandra Reuter ()
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Mabel Budia-Silva: University of Freiburg – Medical Center
Tomislav Kostyanev: University of Antwerp
Stefany Ayala-Montaño: University of Freiburg – Medical Center
Jose Bravo-Ferrer Acosta: Universidad de Sevilla
Maria Garcia-Castillo: Hospital Universitario Ramón y Cajal and Instituto Ramón y Caja de Investigación Sanitaria (IRYCIS)
Rafael Cantón: Hospital Universitario Ramón y Cajal and Instituto Ramón y Caja de Investigación Sanitaria (IRYCIS)
Herman Goossens: University of Antwerp
Jesus Rodriguez-Baño: Universidad de Sevilla
Hajo Grundmann: University of Freiburg – Medical Center
Sandra Reuter: University of Freiburg – Medical Center

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Carbapenem-resistant Klebsiella pneumoniae (CRKP) are of particular concern due to the spread of antibiotic resistance genes associated with mobile genetic elements. In this study, we collected 687 carbapenem-resistant strains recovered among clinical samples from 41 hospitals in nine Southern European countries (2016-2018). We identified 11 major clonal lineages, with most isolates belonging to the high-risk clones ST258/512, ST101, ST11, and ST307. blaKPC-like was the most prevalent carbapenemase-encoding gene (46%), with blaOXA-48 present in 39% of isolates. Through the combination and comparison of this EURECA collection with the previous EuSCAPE collection (2013-2014), we investigated the spread of high-risk clones circulating in Europe exhibiting regional differences. We particularly found blaKPC-like ST258/512 in Greece, Italy, and Spain, blaOXA-48 ST101 in Serbia and Romania, blaNDM ST11 in Greece, and blaOXA-48-like ST14 in Türkiye. Genomic surveillance across Europe thus provides crucial insights for local risk mapping and informs necessary adaptions for implementation of control strategies.

Date: 2024
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DOI: 10.1038/s41467-024-49349-z

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