Protective alleles and precision healthcare in crewed spaceflight

Lindsay A. Rutter, Matthew J. MacKay, Henry Cope, Nathaniel J. Szewczyk, JangKeun Kim, Eliah Overbey, Braden T. Tierney, Masafumi Muratani, Ben Lamm, Daniela Bezdan, Amber M. Paul, Michael A. Schmidt (), George M. Church (), Stefania Giacomello () and Christopher E. Mason ()
Additional contact information
Lindsay A. Rutter: University of Tsukuba
Matthew J. MacKay: Weill Cornell Medicine
Henry Cope: University of Nottingham
Nathaniel J. Szewczyk: University of Nottingham
JangKeun Kim: Weill Cornell Medicine
Eliah Overbey: Weill Cornell Medicine
Braden T. Tierney: Weill Cornell Medicine
Masafumi Muratani: University of Tsukuba
Ben Lamm: Unit #155 Austin
Daniela Bezdan: University of Tübingen
Amber M. Paul: Department of Human Factors and Behavioral Neurobiology
Michael A. Schmidt: Sovaris Aerospace
George M. Church: GC Therapeutics Inc
Stefania Giacomello: KTH Royal Institute of Technology
Christopher E. Mason: Weill Cornell Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Common and rare alleles are now being annotated across millions of human genomes, and omics technologies are increasingly being used to develop health and treatment recommendations. However, these alleles have not yet been systematically characterized relative to aerospace medicine. Here, we review published alleles naturally found in human cohorts that have a likely protective effect, which is linked to decreased cancer risk and improved bone, muscular, and cardiovascular health. Although some technical and ethical challenges remain, research into these protective mechanisms could translate into improved nutrition, exercise, and health recommendations for crew members during deep space missions.

Date: 2024
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DOI: 10.1038/s41467-024-49423-6

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