Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression

Peter Zhukovsky, Earvin S. Tio, Gillian Coughlan, David A. Bennett, Yanling Wang, Timothy J. Hohman, Diego A. Pizzagalli, Benoit H. Mulsant, Aristotle N. Voineskos () and Daniel Felsky ()
Additional contact information
Peter Zhukovsky: Centre for Addiction and Mental Health
Earvin S. Tio: Centre for Addiction and Mental Health
Gillian Coughlan: Massachusetts General Hospital
David A. Bennett: RUSH Medical College
Yanling Wang: RUSH Medical College
Timothy J. Hohman: Vanderbilt University Medical Center
Diego A. Pizzagalli: McLean Hospital
Benoit H. Mulsant: Centre for Addiction and Mental Health
Aristotle N. Voineskos: Centre for Addiction and Mental Health
Daniel Felsky: University of Toronto

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Approximately 40% of dementia cases could be prevented or delayed by modifiable risk factors related to lifestyle and environment. These risk factors, such as depression and vascular disease, do not affect all individuals in the same way, likely due to inter-individual differences in genetics. However, the precise nature of how genetic risk profiles interact with modifiable risk factors to affect brain health is poorly understood. Here we combine multiple data resources, including genotyping and postmortem gene expression, to map the genetic landscape of brain structure and identify 367 loci associated with cortical thickness and 13 loci associated with white matter hyperintensities (P

Date: 2024
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DOI: 10.1038/s41467-024-49430-7

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